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IGFBP-2 Protein, Human

Insulin-like growth factor-binding protein 2,IBP-2,IGF-binding protein 2,IGFBP-2

价格 ￥800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040376
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor-binding protein 2; IBP-2; IGF-binding protein 2; IGFBP-2;

  • Accession

    P18065

  • 表达序列

    Glu37-Gln325

  • 表达宿主

    CHO

  • 分子量

    33 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 0.1μg/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Oncogene. 2020 Mar;39(11):2243-2257.

背景介绍

  • IGFBP-2, or insulin-like growth factor binding protein 2, is a member of the high-affinity binding protein family (IGFBP1-6) and plays a significant role in the regulation of insulin-like growth factors (IGFs) in the central nervous system. This protein is part of a family of six similar proteins that bind to IGF-I and IGF-II, influencing their bioavailability and activity in metabolic signaling. IGFBP-2 can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with various ligands. High expression levels of IGFBP-2 are associated with the growth of several types of tumors and may predict patient recovery chances.
    In the biotechnology and pharmaceutical industries, IGFBP-2 is of significant interest due to its implications in various diseases and conditions. The protein's role in tumor growth makes it a potential biomarker and therapeutic target for cancer research. Elevated levels of IGFBP-2 during the progression of many human cancers suggest its importance in oncology.
    Additionally, IGFBP-2's involvement in metabolic signaling pathways positions it as a key player in the study and treatment of obesity, diabetes, and other metabolic diseases.

  • 生物活性

    • Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on MCF‑7 human breast cancer cells. The ED50 for this effect is 27-77 ng/mL in the presence of 14 ng/mL rhIGF-II.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

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