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Osteopontin Protein, Human

Osteopontin,OPN,Bone sialoprotein 1,Nephropontin,Secreted phosphoprotein 1 (SPP-1),Urinary stone protein,Uropontin

价格 ￥400.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040366
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Osteopontin; OPN; Bone sialoprotein 1; Nephropontin; Secreted phosphoprotein 1 (SPP-1); Urinary stone protein; Uropontin;

  • Accession

    P10451

  • 表达序列

    Ile17-Asn314

  • 表达宿主

    HEK293

  • 分子量

    43 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 0.5μg/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Science. 2000 Feb 4;287(5454):860-4.
    Exp Oncol. 2004 Sep;26(3):179-84.

背景介绍

  • Osteopontin (OPN), also known as secreted phosphoprotein 1 (SPP1), is a multifunctional glycoprotein that is expressed in various tissues and cell types in humans. OPN plays a critical role in diverse biological processes, including bone remodeling, immune response, inflammation, and tissue repair. In the context of bone metabolism, OPN is involved in regulating osteoclast and osteoblast activity, as well as in the mineralization of bone matrix. OPN also functions as a cytokine and adhesive protein, mediating cell-cell and cell-matrix interactions, and modulating immune cell function and inflammatory responses. Dysregulation of OPN expression has been associated with various diseases, such as osteoporosis, cancer, and autoimmune disorders, highlighting the importance of OPN in physiological and pathological conditions.

  • 生物活性

    • Determined by its ability to enhance cell adhesion of murine B16-F1 cells.The EC50 for this effect is less than 10ng/mL.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

    • >95% as determined by RP-HPLC.

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