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GDF-6/BMP-13 Protein, Human

Growth/differentiation factor 6,GDF-6,Bone morphogenetic protein 13 (BMP-13),Growth/differentiation factor 16

价格 ￥600.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040365
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Growth/differentiation factor 6; GDF-6; Bone morphogenetic protein 13 (BMP-13); Growth/differentiation factor 16;

  • Accession

    Q6KF10

  • 表达序列

    Thr336-Arg455

  • 表达宿主

    E.coli

  • 分子量

    15-16 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 3.0μg/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    4mM HCl

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in 4mM HCl after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nature. 1994 Apr 14;368(6472):639-43.
    Development. 1999 Mar;126(6):1305-15.

背景介绍

  • Growth differentiation factor 6 (GDF-6), also known as bone morphogenetic protein 13 (BMP-13), is a member of the transforming growth factor-beta (TGF-β) superfamily of cytokines that plays a critical role in skeletal development and joint maintenance. In humans, GDF-6 is expressed in various tissues, including cartilage, bone, and synovium, and is involved in regulating chondrogenesis, osteogenesis, and joint homeostasis. GDF-6 exerts its biological effects by binding to specific cell surface receptors, such as the BMP receptors, leading to the activation of downstream signaling pathways, including Smad and non-Smad pathways. Through its signaling activities, GDF-6 promotes the differentiation of mesenchymal stem cells into chondrocytes and osteoblasts, as well as the maintenance of cartilage integrity and joint function. GDF-6 is considered a key regulator of skeletal development and joint health, with implications for musculoskeletal disorders and regenerative medicine.

  • 生物活性

    • Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.1-2.8 ug/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

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