gAcrp30/gAdiponectin Protein, Human
Adiponectin,30 kDa adipocyte complement-related protein,Adipocyte complement-related 30 kDa protein (ACRP30),Adipocyte,C1q and collagen domain-containing protein,Adipose most abundant gene transcript 1 protein,Gelatin-binding protein
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物种
Human分子别名
Adiponectin; 30 kDa adipocyte complement-related protein; Adipocyte complement-related 30 kDa protein (ACRP30); Adipocyte, C1q and collagen domain-containing protein; Adipose most abundant gene transcript 1 protein; Gelatin-binding protein;Accession
Q15848表达序列
Ala108-Asn244
表达宿主
E.coli分子量
17 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
EC50 < 1.0 μg/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 200mM NaCl, pH8.0
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Nat Med. 2007 Mar;13(3):332-9. Epub 2007 Feb 1.
Globular adiponectin (gAcrp30), also known as globular adiponectin or gAdiponectin, is a biologically active form of the adipokine adiponectin that plays a key role in regulating metabolism, insulin sensitivity, and inflammation. In humans, adiponectin is predominantly produced by adipocytes and circulates in the bloodstream in different isoforms, including the globular form. gAcrp30 is generated by proteolytic cleavage of full-length adiponectin and exerts its biological effects by binding to adiponectin receptors, AdipoR1 and AdipoR2, leading to the activation of signaling pathways such as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-α). gAcrp30 has been shown to have anti-inflammatory, anti-diabetic, and cardioprotective properties, as well as the ability to regulate lipid metabolism and insulin sensitivity.
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
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