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物种
Rat分子别名
Interleukin-11; IL-11;Accession
Q99MF5表达序列
Pro22-Leu199
表达宿主
E.coli分子量
21 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
EC50 < 5.0ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 300mM NaCl, pH8.0
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Cancer Cell. 2013 Aug 12;24(2):257-71.
Interleukin-11 (IL-11) is a cytokine belonging to the IL-6 family that plays a crucial role in various physiological processes, including hematopoiesis, bone metabolism, and gastrointestinal mucosal protection. In rats, IL-11 is primarily produced by stromal cells in the bone marrow and other cell types, such as fibroblasts and endothelial cells. IL-11 exerts its biological effects by binding to the IL-11 receptor complex, which consists of IL-11Rα and gp130 subunits, leading to the activation of signaling pathways such as the JAK-STAT pathway. IL-11 has been shown to promote the growth and differentiation of hematopoietic progenitor cells, stimulate platelet production, and enhance bone formation. Additionally, IL-11 has anti-inflammatory properties and is being investigated for its potential therapeutic applications in conditions such as osteoporosis and inflammatory bowel disease.
生物活性
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The EC50 for this effect is less than 20ng/ml.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
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