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物种
Human分子别名
Interleukin-20,IL-20,Cytokine Zcyto10,Accession
Q9NYY1表达序列
Leu25-Glu176表达宿主
E.coli分子量
18 kDa (Reducing)
纯度
>95% by SDS-PAGE.内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Annu Rev Immunol. 2011:29:71-109.
Interleukin-20 (IL-20) is a member of the IL-10 cytokine family that plays a role in regulating inflammatory and immune responses. In humans, IL-20 is produced by activated monocytes, keratinocytes, and other cell types in response to pro-inflammatory stimuli. IL-20 signals through a receptor complex composed of IL-20R1 and IL-20R2 subunits, leading to the activation of downstream signaling pathways, including the JAK-STAT pathway. IL-20 has been implicated in various inflammatory conditions, including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. It exerts its biological effects by promoting the production of pro-inflammatory cytokines, chemokines, and matrix metalloproteinases, contributing to tissue inflammation and remodeling.
电泳
2μg (R: reducing condition, N: non-reducing condition).
SPR
Protein A Chip captured Human IL-20 R alpha Protein, Fc Tag, can bind IL-20 Protein, Human (Cat. No. UA040358) with an affinity constant of 3.63μM as determined in SPR assay.
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