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物种
Mouse分子别名
Interferon beta; IFN-beta; Ifnb1; Ifb; Ifnb;Accession
P01575表达序列
Ile22-Asn182, with C-terminal His Tag
表达宿主
HEK293分子量
30-40 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
EC50 < 1.5ng/ml标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Nat Rev Immunol. 2014 Jan;14(1):36-49.
Interferon beta (IFN-β) is a type I interferon that plays a critical role in the immune response to viral infections and other pathogens. In mice, IFN-β is produced by various cell types, including fibroblasts, macrophages, and dendritic cells, in response to viral infection or other stimuli. Upon secretion, IFN-β binds to the interferon alpha/beta receptor (IFNAR) on target cells, leading to the activation of signaling pathways that induce the expression of interferon-stimulated genes (ISGs). These ISGs have antiviral, immunomodulatory, and anti-proliferative effects, contributing to the host defense against viral infections and the regulation of immune responses. IFN-β is also used as a therapeutic agent for the treatment of multiple sclerosis due to its immunomodulatory properties.
生物活性
Measured in antiviral assays using L929 cells infected with vesicular stomatitisvirus (VSV). The EC50 for this effect is 1.7 pg/mL.
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
引用文献(1)
- Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFN-γ-ΙRF1-SREBF2 Axis
L Xu, X Zhang, X Lai, H Chen, S Liao… - Cancer Immunology …, 2025 - aacrjournals.org
Cancer Immunol Res. 2025 Dec 09 .
影响因子： 8.2
货号：UA040355产品名称：IFN-β Protein, Mouse
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