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IL-28B/IFN-λ3 Protein, Human

Interferon lambda-3,IFN-lambda-3,Cytokine Zcyto22,Interleukin-28B (IL-28B),Interleukin-28C (IL-28C)

价格 ￥820.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040344
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Interferon lambda-3; IFN-lambda-3; Cytokine Zcyto22; Interleukin-28B (IL-28B); Interleukin-28C (IL-28C);

  • Accession

    Q8IZI9

  • 表达序列

    Val22-Val196

  • 表达宿主

    E.coli

  • 分子量

    18 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE; >90% by HPLC.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 = 1-3ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    ·3 months, -20 to -80℃ under sterile conditions after reconstitution.
    ·1 week, 2 to 8℃ under sterile conditions after reconstitution.
    ·Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798-801.

背景介绍

  • Interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a type III interferon that plays a crucial role in the innate immune response against viral infections. IFN-λ3 is produced in response to viral stimuli and exerts potent antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. Similar to other type III interferons, IFN-λ3 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ3 has been implicated in the immune response to various viral infections, including hepatitis C virus (HCV) and influenza virus, and is considered a promising therapeutic target for the treatment of viral diseases.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >90% as determined by RP-HPLC.

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