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物种
Rat分子别名
Macrophage colony-stimulating factor 1; CSF-1; MCSF; Proteoglycan acrophage colony-stimulating factor; PG-M-CSF;Accession
Q8JZQ0表达序列
Glu33-Pro186
表达宿主
E.coli分子量
18 kDa (Reducing)
纯度
>95% by SDS-PAGE.内毒素含量
<0.1EU/μg活性
EC50 < 5.0ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 100mM NaCl, pH8.0
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
Blood. 2012 Feb 23;119(8):1810-20.
Macrophage colony-stimulating factor (M-CSF), also known as colony-stimulating factor 1 (CSF-1), is a cytokine that plays a crucial role in the differentiation, proliferation, and survival of monocytes and macrophages. M-CSF is produced by various cell types, including fibroblasts, endothelial cells, and immune cells, and acts through binding to its receptor, CSF-1R, to regulate the development and function of macrophages in the immune system. In rats, M-CSF is essential for the maintenance of tissue homeostasis, immune responses, and inflammatory processes. Studies on rat M-CSF have focused on its role in regulating macrophage populations, tissue repair, and immune responses in various disease models.
生物活性
Measured in a cell proliferation assay using Murine M-NFS-60 cells, the EC50 for this effect is less than 2ng/ml
电泳
2μg (R: reducing condition, N: non-reducing condition).
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