热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 蛋白 细胞因子

所有图片（1/3）

FGF-basic (145aa) Protein, Mouse

Fibroblast growth factor 2,FGF-2,Basic fibroblast growth factor (bFGF),Heparin-binding growth factor 2 (HBGF-2)

价格 ￥360.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040339
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor (bFGF); Heparin-binding growth factor 2 (HBGF-2);

  • Accession

    P15655

  • 表达序列

    Pro10-Ser154

  • 表达宿主

    E.coli

  • 分子量

    17 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE.

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 0.2ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 600mM NaCl,1mM DTT, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Nat Rev Drug Discov. 2009 Mar;8(3):235-53.

背景介绍

  • Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a highly conserved protein consisting of 145 amino acids. It belongs to the fibroblast growth factor family and is known for its potent mitogenic and angiogenic properties. FGF-basic plays a crucial role in various cellular processes, including cell proliferation, differentiation, and tissue regeneration. It exerts its biological effects by binding to FGF receptors and activating downstream signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways. Due to its ability to stimulate cell growth and promote angiogenesis, FGF-basic has been extensively studied for its therapeutic potential in tissue repair, wound healing, and regenerative medicine.

  • 生物活性

    • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 0.2ng/ml.

    • Mouse Gastric organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), Wnt Surrogate(UA040250), KGF/FGF-7(UA040110) and FGF-basic(UA040339)

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

评论(0)