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物种
Rat分子别名
Fibroblast growth factor 2,FGF-2,Basic fibroblast growth factor (bFGF),Heparin-binding growth factor 2 (HBGF-2),Accession
P13109表达序列
Pro10-Ser154表达宿主
E.coli分子量
17 kDa (Reducing)
纯度
>95% by SDS-PAGE.内毒素含量
<0.1EU/μg活性
EC50 < 0.2ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 600mM NaCl,1mM DTT, pH8.0溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Nat Rev Drug Discov. 2009 Mar;8(3):235-53.
Fibroblast Growth Factor-basic (FGF-basic), also known as FGF-2, is a highly conserved protein consisting of 145 amino acids. It belongs to the fibroblast growth factor family and is known for its potent mitogenic and angiogenic properties. FGF-basic plays a crucial role in various cellular processes, including cell proliferation, differentiation, and tissue regeneration. It exerts its biological effects by binding to FGF receptors and activating downstream signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways. Due to its ability to stimulate cell growth and promote angiogenesis, FGF-basic has been extensively studied for its therapeutic potential in tissue repair, wound healing, and regenerative medicine.
生物活性
Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 0.2ng/ml.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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