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Epiregulin Protein, Human

Epiregulin,EPR

价格 ￥880.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040323
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Epiregulin; EPR

  • Accession

    O14944

  • 表达序列

    Val63-Leu108, with N terminal hIgG1 Fc

  • 表达宿主

    HEK293

  • 分子量

    33 kDa (Reducing)

  • 纯度

    >95% by SDS-PAGE and HPLC.

  • 活性

    EC50 < 20 ng/ml

  • 标记

    Unconjugated

  • 标签

    Human IgG1 Fc

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Gene.2006 Jan 17;366(1):2-16. Epub 2005 Dec 27.

背景介绍

  • Epiregulin is a member of the epidermal growth factor (EGF) family of proteins that plays a crucial role in cell signaling and regulation. It acts as a ligand for the epidermal growth factor receptor (EGFR) and is involved in various cellular processes, including cell proliferation, survival, migration, and differentiation. Epiregulin exerts its cellular activities by binding to EGFR and activating downstream signaling pathways, such as the MAPK/ERK and PI3K/Akt pathways, which regulate gene expression and cellular responses. The dysregulation of epiregulin signaling has been implicated in cancer development, metastasis, and resistance to therapy, highlighting its importance in cellular homeostasis and disease progression.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • >95% as determined by SEC-HPLC.

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