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物种
Human分子别名
Defensin beta 4A,Beta-defensin 2,Defensin,beta 2,Skin-antimicrobial peptide 1 (SAP1),Accession
O15263表达序列
Gly24-Pro64表达宿主
E.coli分子量
5 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
EC50 = 0.8-1.2 ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Science. 2002 Nov 1;298(5595):1025-9.
Beta-defensin 2 is a key component of the innate immune system, known for its antimicrobial properties and immunomodulatory functions. It is produced by various epithelial cells in response to microbial infections and plays a crucial role in host defense against pathogens. Beta-defensin 2 exhibits potent antimicrobial activity against a wide range of microorganisms, including bacteria, fungi, and viruses, by disrupting their cell membranes. In addition to its direct antimicrobial effects, beta-defensin 2 also functions as a chemoattractant for immune cells, such as neutrophils, monocytes, and dendritic cells, promoting their recruitment to sites of infection. Furthermore, beta-defensin 2 can modulate inflammatory responses by regulating cytokine production and promoting wound healing.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
ELISA
Measured by its binding ability in a functional ELISA. When Anti-BD-2 Recombinant Antibody is immobilized 0.5µg/mL (100µL/well), Recombinant Human BD-2 binds with an EC50 of 0.8-1.2ng/ml.
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