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物种
Mouse分子别名
Interferon lambda-3,IFN-lambda-3,Interleukin-28B (IL-28B)Accession
Q8CGK6表达序列
Asp20-Val193, with C-terminal 8*His表达宿主
HEK293分子量
24-30 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 2009;461(7265):798-801.
Interferon lambda 3 (IFN-λ3), also known as interleukin-28B (IL-28B), is a type III interferon that plays a crucial role in the innate immune response against viral infections. IFN-λ3 is produced in response to viral stimuli and exerts potent antiviral effects by inducing the expression of interferon-stimulated genes (ISGs) that inhibit viral replication and spread. Similar to other type III interferons, IFN-λ3 signals through the IFN-λ receptor complex, which consists of IL-10R2 and IL-28Rα subunits, leading to the activation of downstream signaling pathways involved in antiviral defense. IFN-λ3 has been implicated in the immune response to various viral infections, including hepatitis C virus (HCV) and influenza virus, and is considered a promising therapeutic target for the treatment of viral diseases.
电泳
2μg (R: reducing condition, N: non-reducing condition).
体积排阻色谱(SEC-HPLC)
>95% as determined by SEC-HPLC.
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