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物种
Human分子别名
C-C motif chemokine 14,Chemokine CC-1/CC-3 (HCC-1/HCC-3),HCC-1(1-74),NCC-2,Small-inducible cytokine A14,Accession
Q16627表达序列
Thr22-Asn93表达宿主
E.coli分子量
8.4 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM PB, 500mM NaCl, pH7.0溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
BMC Genomics. 2008 May 15:9:222.
CCL14, also known as HCC-1, is a chemokine belonging to the CC chemokine family. It is primarily expressed in hematopoietic cells and plays a role in regulating immune responses and inflammation. HCC-1 functions as a chemoattractant for various immune cells, including monocytes, dendritic cells, and lymphocytes, by binding to its cognate receptor, CCR1. This interaction leads to the recruitment of immune cells to sites of inflammation or infection.
In addition to its chemotactic properties, HCC-1 has been implicated in modulating immune cell activation and differentiation. It can influence the polarization of T cells towards specific effector phenotypes, such as Th1 or Th2 cells, by regulating the expression of cytokines and chemokines. HCC-1 is also involved in the regulation of inflammatory responses and has been linked to the pathogenesis of inflammatory diseases.
Overall, HCC-1 plays a crucial role in orchestrating immune cell trafficking and activation, contributing to the regulation of immune responses and inflammation in various physiological and pathological conditions.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
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