SDF-1α/CXCL12 Protein, Mouse
Stromal cell-derived factor,SDF-1,12-O-tetradecanoylphorbol 13-acetate repressed protein 1 (TPAR1),C-X-C motif chemokine 12,Pre-B cell growth-stimulating factor (PBSF),Thymic lymphoma cell-stimulating factor (TLSF)
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物种
Mouse分子别名
Stromal cell-derived factor,SDF-1,12-O-tetradecanoylphorbol 13-acetate repressed protein 1 (TPAR1),C-X-C motif chemokine 12,Pre-B cell growth-stimulating factor (PBSF),Thymic lymphoma cell-stimulating factor (TLSF)Accession
P40224表达序列
Lys22-Lys89表达宿主
E.coli分子量
8 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 300mM NaCl, pH8.0溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
J Mol Med (Berl). 2014 May; 92(5):433-9.
Nat Rev Immunol. 2011 Aug 25;11(9):597-606.
SDF-1α, also known as CXCL12, is a chemokine protein that plays a critical role in immune cell trafficking, hematopoiesis, and tissue repair. It is produced by stromal cells, endothelial cells, and other cell types in response to various stimuli, including inflammation and tissue injury. SDF-1α/CXCL12 exerts its biological effects by binding to its receptor CXCR4, a G protein-coupled receptor expressed on the surface of immune cells, hematopoietic stem cells, and other cell types.
The protein structure of SDF-1α/CXCL12 consists of a conserved N-terminal region and a flexible loop region, which is important for receptor binding and activation of downstream signaling pathways. The interaction between SDF-1α/CXCL12 and CXCR4 regulates the migration, homing, and retention of immune cells in specific tissues, as well as the mobilization and homing of hematopoietic stem cells.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
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