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物种
Human分子别名
C-C motif chemokine 4,LAG-1,Macrophage inflammatory protein 1-beta,SCYA4Accession
P13236表达序列
Ala24-Asn92表达宿主
E.coli分子量
15kDa (Reducing)
纯度
＞95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
Progress in Test标记
Unconjugated性状
Lyophilized Powder缓冲体系
20mM Tris, 300mM NaCl, pH8.0溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1. T Nguyen-Hoai (2016) Cancer Gene Ther. 23(6):162-7.
2. Dabin Lee (2018) Cell Death Dis . 9(5):495.
CCL4 (macrophage inflammatory protein-1β, MIP-1β) is a CC chemokine that belongs to the group of inflammatory chemokines and acts as a chemoattractant for different immune effector cells such as immature DC, TH1 T cells, NK cells and monocytes. In contrast to CCR7 that is expressed on mature DC and naive T-cell subsets, the CCL4 receptor CCR5 is expressed on immature DC and TH1-polarized T cells. CCL4 can activate chemokine receptor CCR5, which is involved in diverse immune responses. Among the diverse chemokines, CCL4 and its receptor CCR5 have been a focus of research on HIV. CCL4 is also secreted by CD8 + T cells and attracts monocytes, natural killer cells, and other immune cells.
电泳
1μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
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