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物种
Human分子别名
IL18BP,IL18BPa,Tadekinig-alfaAccession
O95998表达序列
Thr31-Gly194表达宿主
E.coli分子量
18kDa (Reducing)纯度
＞95% by SDS-PAGE&RP-HPLC内毒素含量
<0.1EU/μg活性
<2ng/mL标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Review Front ImmunoQl. 2013 Oct 8;4:289.
Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. According to the other study, IL1R9 is evolutionarily related to IL18BP and may function as an IL-18 receptor. Plasma il-18 /IL18BP levels increase during disease activity, suggesting that it may play a role in the pathogenesis of ITP.
生物活性
Measured by its ability to inhibit the IL-18-induced response of KG 1 human acute myelogenous leukemia cells. The EC50 for this effect is less than 2ng/mL in the presence of 20 ng/mL of recombinant human IL-18
电泳
1μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
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