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产品中心 细胞因子 白细胞介素

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IL-2 Protein, Rat

TCGF,IL2,Interleukin 2,T Cell Growth Factor,Aldesleukin,IL-2,Involved In Regulation Of T-Cell Clonal Expansion,Interleukin-2,Lymphokine

价格 ￥580.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040229
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    TCGF，IL2，Interleukin 2，T Cell Growth Factor，Aldesleukin，IL-2，TCGF，Involved In Regulation Of T-Cell Clonal Expansion，Interleukin-2，Lymphokine

  • Accession

    P17108

  • 表达序列

    Ala21-Gln155

  • 表达宿主

    E.coli

  • 分子量

    16kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE&RP-HPLC

  • 内毒素含量

    <0.1EU/μg

  • 活性

    <0.2 ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    50mM NaAc,150mM NaCl,pH5.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Pol, J. G. , Caudana, P. , Paillet, J. , Piaggio, E. , & Kroemer, G. . (2020).

    2.Effects of interleukin-2 in immunostimulation and immunosuppression. The Journal of Experimental Medicine(1), 217.

    3.Kolios, A. G., Tsokos, G. C., & Klatzmann, D. (2021). Interleukin-2 and regulatory T cells in rheumatic diseases. Nature Reviews Rheumatology, 17(12), 749-766. Zhang, Y., & Su, J. (2023).

    4.Interleukin-2 family cytokines: An overview of genes, expression, signaling and functional roles in teleost. Developmental & Comparative Immunology, 104645.

背景介绍

  • Interleukin 2 (IL 2), also termed T-cell growth factor, is a member of the cytokine family which includes IL-4, IL-7, IL-9, IL-15 and IL-21. Each member of this family has a four alpha helix bundle. IL-2 signals through the IL-2 receptor, a complex consisting of tree subunits, termed alpha, beta and gamma. The IL-2 R gamma is shared by cytokine receptors of all members of cytokine family. Mature mouse IL­2 shares 56% and 73% aa sequence identity with human and rat IL­2, respectively. IL-2 is produced by CD4+ T cell, CD8+ T cells, gamma δ T cells, B cells, dendritic cells and eosinophils, and plays a vital role in key function of the immune system, tolerance and immunity, primarily via its potent stimulatory activity for T cells.Thus, IL­2 may be a key cytokine in the natural suppression of autoimmunity.

  • 生物活性

    • Measured in a cell proliferation assay using CTLL2. The ED50 for this effect is typically 1.9-2.3 ng/mL.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

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