热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 细胞因子 白细胞介素

所有图片（1/4）

IL-31 Protein, Human

IL-31,IL31,Interleukin-31

价格 ￥1,080.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040227
规格
数量
收藏 分享

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IL-31,IL31,Interleukin-31

  • Accession

    Q6EBC2

  • 表达序列

    Ser24-Thr164

  • 表达宿主

    E.coli

  • 分子量

    16kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    EC50 < 30ng/ml

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM PB, 100mM NaCl, pH6.5

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.J Allergy Clin Immunol. 2023 Jul 13;S0091-6749(23)00888-6. Online ahead of print.
    2. Allergy. 2023 Jul 13. Online ahead of print.
    3. Clin Exp Med. 2023 Jul 1. Online ahead of prin

  • 稀释度

背景介绍

  • IL-31 which produced by activated Th2-type T cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.

  • 生物活性

    • Measured by its ability to induce STAT3 activation in U‑87 MG human glioblastoma/astrocytoma cells. The EC50 for this effect is less than 30ng/ml can effectively induce STAT3 activation.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • ELISA

    • Measured by its binding ability in a functional ELISA. When Recombinant Human IL-31 is immobilized 2.5µg/mL (100µL/well), Recombinant Human OSMR/IL-31RB His Tag binds with an EC50 of 1.3-1.6μg/ml.

    • Measured by its binding ability in a functional ELISA. When Recombinant Human IL-31 is immobilized 2.5µg/mL (100µL/well), Recombinant Mouse IL-31RA Fc chimera binds with an EC50 of 0.07-0.1μg/ml.

    评论(0)