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产品中心 细胞因子 白细胞介素

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IL-3 Protein, Rat

IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3

价格 ￥880.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040219
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    IL3, MCGF, MGC79398, MGC79399, MULTI-CSF, Interleukin-3

  • Accession

    P04823

  • 表达序列

    Ser28-Cys166

  • 表达宿主

    E.coli

  • 分子量

    16kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 活性

    ＜3ng/mL

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM PB, 200mM NaCl, pH6.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Gröger M. (2004) IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. J Immunol. 173(12):7161-7169.

    2.Hawwari A. (2002) The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities. J Immunol. 169(4): 1876-1886.

背景介绍

  • IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. Interleukin-3 is a cytokine that regulates the proliferation, differentiation, activation, and survival of myeloid progenitor cells and the mast cells, eosinophils, basophils, neutrophils, monocytes, megakaryocytes, and erythroid cells that they give rise to (1–3). Although IL-3 was first defined as a CSF (multi-CSF), it is not essential to hemopoiesis, and it may function in vivo pre dominantly as a proinflammatory cytokine activating mature myeloid cells. The IL-3 gene exists within a one megabase conserved cytokine gene cluster that also contains the genes for IL-4, IL-5, IL-13, and GM-CSF. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

  • 生物活性

    • Measured in a cell proliferation assay using Murine M-NFS-60 cells, the EC50 for this effect is less than 6ng/mL.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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