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物种
Mouse分子别名
IL-21B,IFNL3Accession
Q8CGK6表达序列
Asp20-Val193
表达宿主
E.coli分子量
20kDa (Reducing)
纯度
>95% by SDS-PAGE
内毒素含量
<0.1EU/μg活性
Test in progress.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
1. Sci Rep. 2020 Dec 1;10(1):20973.
2. Int Immunopharmacol. 2022 Aug:109:108799. Epub 2022 May 4.
IL-28 is a family of cytokines that belongs to interferons termed as λ-interferons or type III interferons (IFN). This family includes IL-28A(IFN-λ2), IL-28B(IFN-λ3) and IL-29(IFN-λ1) in human and IL-28A and IL-28B in mice. IL-28A, IL-28B and IL-29 share a unique heterodimeric receptor IFNLR consisting of IL-28Rα and IL-10R, which is mainly expressed by epithelial cells, dendritic cells (DCs) and macrophages. IL-28B inhibits M2 macrophage polarization in vitro, while also halting M2 macrophage differentiation predominantly via inhibition of the signal transducer and activator of transcription (STAT)3 and c-Jun N-terminal kinase (JNK) signaling pathways. Results reveal a protective role of IL-28B via regulation of epithelial cells in protease induced asthma.
生物活性
Measured in antiviral assays using HepG2 cells infected with vesicular stomatitis virus. The ED50 for this effect is 10-60 ng/ml.
电泳
1μg (R: reducing condition, N: non-reducing condition).
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