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产品中心 细胞因子 趋化因子及其受体

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Eotaxin/CCL11 Protein, Human

C-C motif chemokine 11,Eosinophil chemotactic protein,Small-inducible cytokine A11

价格 ￥680.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040163
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    C-C motif chemokine 11,Eosinophil chemotactic protein,Small-inducible cytokine A11

  • Accession

    P51671

  • 表达序列

    Gly24-Pro97

  • 表达宿主

    E.coli

  • 分子量

    10kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4.

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    Acta Neurol Belg. 2022; 122(4): 865–869. Pharmaceuticals (Basel). 2020 Sep; 13(9): 230.

背景介绍

  • Eotaxin/CCL11, produced by eosinophils, B-cells, fibroblasts, endothelial cells, macrophages, chondrocytes and other cells, is a member of the eotaxin family that is chemotactic agents for eosinophils and participate in innate immunity. It is induced by T helper-2 cytokines, like IL-13, IL-10 and IL-4, then transported from the blood to the brain through the Blood-Brain Barrier (BBB). Eotaxin/CCL11 may exert physiological and pathological functions in the central nerve system, and may induce neuronal cytotoxicity effects by inducing the production of reactive oxygen species (ROS) in microglia cells. Plasma levels of CCL11 elevated in neuroinflammation and neurodegenerative disorders.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

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