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物种
Human分子别名
NRG1-β1,Pro-neuregulin-1,Neuregulin-1 beta 1,NRG1-beta 1,HRG1-beta 1,EGF,NRG1,GGF,HGL,HRGA,NDF,SMDFAccession
Q02297-6表达序列
Ser177-Glu241表达宿主
E.coli分子量
7-8kDa (Reducing)
纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg活性
<3ng/mL标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS,pH7.4.
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
Cell Rep. 2021 Sep 7;36(10):109656.
Cell Rep. 2021 Aug 17;36(7):109538.
Heregulin-β also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases. And NRG1 isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. The NRG1 receptors are membrane-spanning receptor tyrosin kinases of the ErbB family (ErbB1–4), of which the EGF receptor (ErbB1) is the most prominent representative.
生物活性
Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The EC50 for this effect is less than 5ng/mL.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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