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物种
Human分子别名
Interleukin-34; IL-34;Accession
Q6ZMJ4表达序列
Asn21-Pro242, with C-terminal His Tag
表达宿主
CHO分子量
30-38 kDa (Reducing)
纯度
>95% by SDS-PAGE and HPLC.内毒素含量
<0.1EU/μg活性
EC50 = 1.5-3.6 ng/ml标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
20mM Tris, 300mM NaCl, pH8.0
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
·12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
·3 months, -20 to -80℃ under sterile conditions after reconstitution.
·1 week, 2 to 8℃ under sterile conditions after reconstitution.
·Please avoid repeated freeze-thaw cycles.文献引用
Science. 2008 May 9;320(5877):807-11.
Nat Immunol. 2012 Jun 24;13(8):753-60.
Interleukin-34 (IL-34) is a cytokine that was discovered in 2008 through functional screening of the extracellular proteome. It shares many functional similarities with colony-stimulating factor 1 (CSF-1), as both can bind to the CSF-1 receptor (CSF-1R) and regulate the differentiation and function of monocytes and macrophages. IL-34 is expressed in various tissues, including the brain, skin, and immune organs, and plays important roles in immune regulation, tissue homeostasis, and inflammation.
The IL-34/CSF-1R axis is a potential therapeutic target for various diseases, including cancer, inflammatory diseases, and autoimmune disorders. Also, IL-34 can serve as a biomarker for certain conditions. For instance, its expression levels in tissues or body fluids may indicate the presence or severity of diseases such as liver fibrosis and diabetic complications.
电泳
2μg (R: reducing condition, N: non-reducing condition).
反相高效液相色谱(RP-HPLC)
>95% as determined by RP-HPLC.
ELISA
Immobilized M-CSFR Fc Chimera Protein, Mouse (Cat. No. UA010186) at 5.0μg/mL (100μL/well) can bind IL-34 Protein, Human (UA040153) with EC50 of 8.52-15.74 ng/mL.
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