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EGF Protein, Mouse

Urogastrone,URG,Epidermal Growth Factor

价格 ￥200.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040126
规格
数量
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产品介绍

产品介绍 引用文献(1) 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    Urogastrone,URG,Epidermal Growth Factor

  • Accession

    P01132

  • 表达序列

    Asn977-Arg1029

  • 表达宿主

    E.coli

  • 分子量

    6.2kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Cell Biol Int. 1995 May;19(5):413-30.

背景介绍

  • Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. EGF binds to epidermal growth factor receptor and stimulates an intracellular signal transduction cascade, leading to activation of genes that regulate cell proliferation, angiogenesis, motility, and metastasis. EGF mRNA and protein are expressed in a number of adult tissues, especially in epithelial cells in the gastrointestinal tract. Predominant sites of synthesis of this peptide are the submandibular glands, the Brunner glands in the small intestine and the kidney.

  • 生物活性

    • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells. The EC50 for this effect is less than 0.5ng/ml.

    • Mouse bile duct organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), FGF-10(UA040076), HGF(UA040194) and Wnt Surrogate(UA040250).

    • Mouse lung organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), FGF-10(UA040076), HGF(UA040194), Wnt Surrogate(UA040250) and KGF/FGF-7(UA040110)

    • Mouse Gastric organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), Wnt Surrogate(UA040250), KGF/FGF-7(UA040110) and FGF-basic(UA040339)

    • Mouse small intestinal organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), Wnt Surrogate(UA040250).

    • Mouse Colon organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), Wnt Surrogate(UA040250).

  • 电泳

    • 2μg ( R: reducing condition, N: non-reducing condition).

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