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物种
Human分子别名
KITLG,FPH2,KL-1,Kitl,MGF,SCF,SF,SHEP7,KLAccession
P21583表达序列
Glu26-Ala189表达宿主
CHO分子量
16-28kDa
纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg活性
< 5ng/ml标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
文献引用
1. Review Physiol Rev . 2012 Oct;92(4):1619-49.
Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). Stem cell factors perform their biological functions by binding to and activating the receptor tyrosine kinase c-Kit. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. Stem cell factor (SCF) has been shown to stimulate the proliferation of myeloid, erythroid, and lymphoid progenitor cells in bone marrow culture and has been shown to work synergically with colony-stimulating factors.
生物活性
Measured in a cell proliferation assay using human M-07e cells, the EC50 for this effect is less than 5ng/ml.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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