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KGF/FGF-7 Protein, Mouse

Heparin-binding growth factor 7 (HBGF-7),Keratinocyte growth factor (KGF)

价格 ￥700.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040110
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 抗原名称

    KGF/FGF-7

  • 分子别名

    Heparin-binding growth factor 7 (HBGF-7), Keratinocyte growth factor (KGF)

  • Accession

    P36363

  • 表达序列

    Cys32-Thr194

  • 表达宿主

    E.coli

  • 分子量

    20kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE&HPLC

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.MacDonald KP, Hill GR. Keratinocyte Growth Factor (KGF) in hematology and oncology. Curr Pharm Des. 2002;8(5):395-403.
    2.Niu J, Chang Z, Peng B, Xia Q, Lu W, Huang P, Tsao MS, Chiao PJ. Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors. J Biol Chem. 2007 Mar 2;282(9):6001-11. Epub 2007 Jan 2.

背景介绍

  • Keratinocyte growth factor (KGF), also known Fibroblast growth factor 7 (FGF-7) is a member of the fibroblast growth factor (FGF) family, and plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. KGF is also a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblast and endothelial cells. Studies of mouse and rat homologous protein implicated roles in morphogenesis of epithelium, re-epithelialization of wounds, hair development and early lung organogenesis.

  • 生物活性

    • Measured in a serum-free cell proliferation assay using MCF 7 human breast cancer cells. The EC50 for this effect is less than 1ng/ml.

    • Mouse lung organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), FGF-10(UA040076), HGF(UA040194), Wnt Surrogate(UA040250) and KGF/FGF-7(UA040110)

    • Mouse Gastric organoids were cultured with R-spondin-1(UA040525), Noggin(UA040404), EGF(UA040126), Wnt Surrogate(UA040250), KGF/FGF-7(UA040110) and FGF-basic(UA040339)

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

  • 反相高效液相色谱(RP-HPLC)

  • ELISA

    • Immobilized KGF/FGF-7 Protein, Mouse (Cat. No. UA040110) at 2.0μg/mL (100μL/well) can bind FGF-R2(IIIb) Fc Chimera Protein, Human (Cat. No. UA011251) with EC50 of 0.21-0.52μg/mL.

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