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Leptin Protein, Rat

Leptin,rRtLeptin,Obesity protein (OB),LEP

价格 ￥380.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040081
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Rat

  • 分子别名

    Leptin,rRtLeptin,Obesity protein (OB),LEP

  • Accession

    P50596

  • 表达序列

    Val22-Cys167

  • 表达宿主

    E.coli

  • 分子量

    15kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 80mM NaCl, 5%trehalose, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Wodarski K. et al. (2009) Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 11(1): 1-6.

    2、Tezapsidis N. et al. (2009) Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 16(4): 731-740.

    3、Cai C. et al. (2009) Leptin in non-autoimmune inflammation. Inflamm Allergy Drug Targets. 8(4): 285-291.

    4、Fernndez-Riejos P. et al. (2010) Role of leptin in the activation of immune cells. Mediators Inflamm. 2010: 568343.

    5、Kelesidis T. et al. (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 152(2): 93-100.

背景介绍

  • Leptin (LEP) is a 16kDa peptide hormone produced mainly by white adipocyte tissue. Leptin is involved in maintaining gastric epithelial cell integrity and gastroprotection. In rats, systemic leptin is effective in attenuating both ethanol- and aspirin-induced damage to the gastric mucosa. This is correlated with an increase of leptin production by the stomach during experimentally-induced gastric damage in rats and during H pylori infection in humans. This gastric cytoprotective effect of leptin involves an increase in blood flow, local production of nitric oxide and prostaglandin E2, and vagus nerve-dependent mechanisms. One of the important functions of leptin is its role in the regulation of inflammatory processes. There is indeed a large body of evidence that leptin-mediated signal pathways play an active role in innate and adaptive immunity through alteration of various target genes transcription.

  • 生物活性

    • Measured in a cell proliferation assay using LOVO cells, The EC50 for this effect is less than 5μg/ml.

  • 电泳

    • 2μg (R: reducing condition, N: non-reducing condition).


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