热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 细胞因子 生长因子

所有图片（1/3）

IL-3 Protein, Human

IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3

价格 ￥820.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040068
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IL3,MCGF,MGC79398,MGC79399,MULTI-CSF,Interleukin-3

  • Accession

    P08700

  • 表达序列

    Ala20-Phe152

  • 表达宿主

    E.coli

  • 分子量

    16kDa

  • 纯度

    >95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1、Gröger M. (2004) IL-3 induces expression of lymphatic markers Prox-1 and podoplanin in human endothelial cells. J Immunol. 173(12):7161-7169.

    2、Hawwari A. (2002) The human IL-3 locus is regulated cooperatively by two NFAT-dependent enhancers that have distinct tissue-specific activities. J Immunol. 169(4): 1876-1886.

背景介绍

  • IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. Interleukin-3 is a cytokine that regulates the proliferation, differentiation, activation, and survival of myeloid progenitor cells and the mast cells, eosinophils, basophils, neutrophils, monocytes, megakaryocytes, and erythroid cells that they give rise to (1–3). Although IL-3 was first defined as a CSF (multi-CSF), it is not essential to hemopoiesis, and it may function in vivo pre dominantly as a proinflammatory cytokine activating mature myeloid cells. The IL-3 gene exists within a one megabase conserved cytokine gene cluster that also contains the genes for IL-4, IL-5, IL-13, and GM-CSF. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

  • 生物活性

    • Measured in a cell proliferation assay of human TF-1 cells, The EC50 for this effect is less than 0.5ng/ml.

  • 电泳

    • 1μg (R: reducing conditions, N: non-reducing conditions).

  • SPR

    • Protein A Chip captured IL-3 Rα/CD123 Fc Chimera Protein, Human (Cat. No. UA010120), can bind IL-3, Human (Cat. No. UA040068) with an affinity constant of 0.16μM as determined in SPR assay.

评论(0)