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物种
Human分子别名
MCGF,MULTI-CSFAccession
P08700表达序列
Ala20-Phe152表达宿主
E.coli分子量
15kDa (Reducing)
纯度
＞95% by SDS-PAGE内毒素含量
<0.1EU/μg活性
EC50 < 0.1ng/ml.标记
Unconjugated标签
No Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4.溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Marion Gröger. (2004) J Immunol. 173(12):7161-9.
Abbas Hawwari. (2002) J Immunol. 169(4):1876-86.
IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. Interleukin-3 is a cytokine that regulates the proliferation, differentiation, activation, and survival of myeloid progenitor cells and the mast cells, eosinophils, basophils, neutrophils, monocytes, megakaryocytes, and erythroid cells that they give rise to (1–3). Although IL-3 was first defined as a CSF (multi-CSF), it is not essential to hemopoiesis, and it may function in vivo pre dominantly as a proinflammatory cytokine activating mature my eloid cells. The IL-3 gene exists within a one megabase conserved cytokine gene cluster that also contains the genes for IL-4, IL-5, IL-13, and GM-CSF. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
生物活性
Measured in a cell proliferation assay of human TF-1 cells, The EC50 for this effect is less than 0.1ng/ml.
电泳
2μg (R: reducing condition, N: non-reducing condition).
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