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产品中心 细胞因子 生长因子

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FGF-8b Protein, Human

Fibroblast growth factor 8b,FGF8

价格 ￥780.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040027
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Fibroblast growth factor 8b,FGF8

  • Accession

    P55075

  • 表达序列

    Gln23-Arg215

  • 表达宿主

    E.coli

  • 分子量

    25kDa (Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    20mM Tris, 150mM NaCl, 1mM EDTA, pH8.0

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • Fibroblast growth factor 8b (FGF-8b), a secreted heparin-binding protein, is a member of the fibroblast growth factor (FGF) family and is an isoform of FGF-8. Alternative splicing of fgf-8 gene gives rise to potentially four (a, b, e, f) different protein isoforms in human, and FGF-8b exhibits the highest transforming activity in NIH3T3 cells. FGF-8b signals through FGF receptors (FGFRs) to activate PI3K and MAPK pathways. FGF-8b is broadly associated with mitogenic and cell survival activities, and regulates gastrulation, epithelial-mesenchymal transition, and later on mesenchymal to epithelial differentiation during embryonic development. FGF-8b has also been found in peripheral blood leukocytes and healthy bone marrow samples.

  • 生物活性

    • Measured in a cell proliferation assay using Balb/c 3T3 mouse fibroblast cells, the EC50 for this effect is less than 5ng/ml.

  • 电泳

    • 1μg (R: reducing condition, N: non-reducing condition).

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