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产品中心 细胞因子 集落刺激因子

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M-CSF Protein, Human

价格 ￥2,880.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040016
规格
数量
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产品介绍 引用文献(1) 评论(0)

产品规格

  • 物种

    Human

  • Accession

    P09603-3

  • 表达序列

    Glu33-Ser190

  • 表达宿主

    CHO

  • 分子量

    16-23 kDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    No Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

    · Please avoid repeated freeze-thaw cycles.

  • 稀释度

背景介绍

  • Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that regulates the proliferation, differentiation, and functional activation of monocytes. Normally detected in human serum, M-CSF plays an important role in enhancing the effector functions of mature monocytes and macrophages. M-CSF serum levels are increased in CB and further increased in the neonate. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail.

  • 生物活性

    • Measured in a cell proliferation assay using Murine M-NFS-60 cells, The EC50 for this effect is less than 5ng/ml.

  • 电泳

    • 1μg（R: reducing conditions, N: non-reducing conditions).

  • ELISA

    • Immobilized M-CSF Protein, Human (Cat. No. UA040016) at 0.5μg/mL (100μL/well) can bind M-CSFR Fc Chimera Protein, Human (Cat. No. UA010186) with EC50 of 20.45-26.08 ng/mL.

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