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物种
Human分子别名
Macrophage colony-stimulating factor 1,M-CSF,CSF-1,LanimostimAccession
P09603-3表达序列
Glu33-Ser190表达宿主
CHO标记
Unconjugated标签
No Tag缓冲体系
PBS, pH 7.4
溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer Tiantian Ji; Haoyu Fu; Liping Wang; Jinyun Chen; Shaobo Tian; Guobin Wang; Lin Wang; Zheng Wang；PLOS Genetics. 2024 Feb 26 ; 1553-7404
| 项目 | 标准 |
|---|---|
| 性状（冻干粉、液体） | Lyophilized Powder |
| 内毒素 | ＜10 EU/mg |
| 宿主蛋白残留 | ＜500ppm |
| 宿主DNA残留 | ＜100ppb |
| 支原体 | 阴性 |
| 无菌 | 符合 |
| pH值 | 7.2~7.6 |
| 蛋白含量 | 90%~120% |
| SDS-PAGE分子量 | 16~23 kD（还原）&30~40kD（非还原） |
| SDS-PAGE纯度 | >97%（非还原） |
| SEC-HPLC纯度 | >97% |
| 细胞活性 | < 5ng/ml |
Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that regulates the proliferation, differentiation, and functional activation of monocytes. Normally detected in human serum, M-CSF plays an important role in enhancing the effector functions of mature monocytes and macrophages. M-CSF serum levels are increased in CB and further increased in the neonate. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail.
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