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产品中心 细胞因子 白细胞介素

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IL-15 Protein, Human STAR

价格 ￥1,200.00 （现货 ： 2-5个工作日）
货号 UA040010
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 抗原名称

      IL-15

    • Accession

      P40933

    • 表达序列

      Asn49-Ser162

    • 表达宿主

      E.coli

    • 分子量

      12 kDa(Reducing)

    • 纯度

      ＞95% by SDS-PAGE

    • 内毒素含量

      <1EU/μg

    • 活性

      The EC50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be <0.2ng/ml.

    • 标记

      Unconjugated

    • 标签

      No Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • Interleukin-15 (IL-15), a cytokine discovered in 1994, supports the homeostasis of cytotoxic immune cells, exhibits a broad biological activity. IL-15 stimulate the proliferation of activated T cells as well as to facilitate the induction of cytotoxic T-lymphocytes (like CD8+), and the generation, proliferation, and activation of NK cells. Therefore, IL-15 is applied to the rapidly expanding cancer immunotherapy field combining with other agents, i.e., checkpoint inhibitors, monoclonal antibodies, chemotherapy, radiation, and chimeric antigen receptor T (CAR-T) cells, in order to target multiple mechanisms and enhance the immune response against tumors, which provides advantages to control and treat cancers.

    • 生物活性

      • The EC50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 was found to be <0.5ng/ml.

    • 电泳

      • 1μg (N: non-reducing condition, R: reducing condition).

    • ELISA

      • Immobilized IL-15, Human (Cat. No. UA040010) at 2μg/mL (100μL/well) can bind IL-15R alpha/CD215 Fc Chimera, Mouse (Cat. No. UA010314) with EC50 of 18.40-68.11 ng/mL.

      • Immobilized IL-15 Protein, Human (Cat. No. UA040010) at 2.0μg/mL (100μL/well) can bind IL-15R alpha/CD215 Fc Chimera Protein, Human (Cat. No. UA010309) with EC50 of 6.27-8.97ng/mL.

    • SPR

      • Anti-His antibody Immobilized on CM5 Chip captured IL-2R beta/CD122 His Tag, Human (Cat. No. UA010372), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 19.04 nM as determined in SPR assay.

      • Protein A Chip captured IL-15R alpha/CD215 Fc Chimera, Human (Cat. No. UA010309), can bind IL-15, Human (Cat. No. UA040010) with an affinity constant of 4.35 nM as determined in SPR assay.

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