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FGF-21 Protein, Human

FGF-21,Fibroblast Growth Factor 21,FGF21

价格 ￥680.00 （ 供应商现货 ： 3-5个工作日）
货号 UA040001
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      FGF-21;Fibroblast Growth Factor 21, FGF-21, FGF21

    • Accession

      Q9NSA1-1

    • 表达序列

      His29-Ser209, with N-terminal His Tag

    • 表达宿主

      HEK293

    • 分子量

      25-28 KDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.2, 5% trehalose

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • Fibroblast growth factor 21 (FGF-21) is a member of the FGF gene family. According to its structure, it is further classified as a member of the FGF19 subfamily. The subfamily includes FGF-19,-21 and-23. FGF-21 is an effective adipocyte glucose uptake activator that protects animals from diet-induced obesity when overexpressed in transgenic mice and reduces blood glucose and triglyceride levels during treatment in diabetic rodents. Some studies have shown that FGF-21 is a biomarker for the diagnosis of mitochondrial diseases. FGF-21 can cross the blood-brain barrier and regulate the phosphorylation cascade and gene expression in the whole hypothalamus. Intracerebroventricular injection of FGF21 can increase metabolic rate and insulin sensitivity in rats, but the site of action is not clear.

    • 生物活性

      • Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The EC50 this effect is less than 1μg/ml in the presence of 1.5 μg/ml recombinant human Klotho β.

    • 电泳

      • FGF-21 His tag, Human，2μg on SDS-PAGE under Non-reducing and reducing condition. The purity is greater than 95%.

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