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产品中心 药物靶点和Fc受体 药物靶点

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Transthyretin/Prealbumin His Tag Protein, Human

TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651,Transthyretin

价格 ￥1,100.00 （ 供应商现货 ： 3-5个工作日）
货号 UA030086
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    TTR,Prealbumin,TBPA,ATTR,PALB,CTS,CTS1,HsT2651,Transthyretin

  • Accession

    P02766

  • 表达序列

    Gly21-Glu147 with His Tag at the C-Terminus

  • 表达宿主

    HEK293

  • 分子量

    15-20kDa&30-40kDa(Reducing)

  • 纯度

    ＞95% by SDS-PAGE & > 95% SEC-HPLC

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, PH7.4, 5% trehalose

  • 溶解方法

    Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.

  • 文献引用

    1.Alexander KM, Davis MK, Akinboboye O, Berk J, Bhatt K, Cappelli F, Cuddy SAM, Fontana M, Garcia-Pavia P, Gillmore JD, Griffin JM, Grodin JL, Judge DP, Khouri MG, Lam K, Masri A, Maurer MS, Obici L, Ruberg FL, Sarswat N, Shah K, Soman P, Stern L, Wright R, Xiong K, Cao X, Lystig T, Tamby JF, Castaño A, Katz L, Sinha U, Fox JC, Solomon SD, Grogan M. Efficacy of Acoramidis in Wild-Type and Variant Transthyretin Amyloid Cardiomyopathy: Results From ATTRibute-CM and Its Open-Label Extension. JAMA Cardiol. 2025 Nov 8:e254477.
    2.Clark T, Lucas R, Nasuhidehnavi A, Sauers N, Bach K. Acoramidis: A New Transthyretin Stabilizer for Transthyretin Amyloid Cardiomyopathy. Ann Pharmacother. 2

背景介绍

  • Transthyretin (TTR) is a tetramer composed of four identical subunits, with each monomer rich in β-sheets and forming an internal channel within its structure for ligand binding. It primarily functions as a transport carrier in the blood and cerebrospinal fluid, responsible for transporting thyroid hormone thyroxine (T4) and retinol (vitamin A). Genetic mutations or age-related misfolding of TTR can lead to its aggregation into amyloid fibrils, triggering a series of diseases known as transthyretin amyloidosis (ATTR), including both hereditary and wild-type amyloidosis, which can affect multiple organs such as nerves, heart, and eyes. Consequently, this protein is a key target for disease diagnosis, disease monitoring, and emerging therapies (such as stabilizing the tetrameric structure or clearing amyloid deposits).

  • 电泳

    • 2μg (R: reducing condition, N:non-reducing condition).

  • 体积排阻色谱(SEC-HPLC)

    • The purity of Transthyretin/Prealbumin His Tag Protein, Human is more than 95% determined by SEC-HPLC.

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