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物种
Human抗原名称
Transferrin分子别名
Transferrin,TF,DKFZp781D0156,PRO1557,PRO2086Accession
P02787表达序列
Val20-Pro698, with C-terminal 10*His表达宿主
HEK293分子量
75-85kDa
纯度
>95% by SDS-PAGE内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.文献引用
1.Cell.2004 Feb 20;116(4):565-76.
Transferrin is a glycoprotein with an approximate molecular weight of 76.5kDa. Transferrin is also known as Serotransferrin, Beta-1 metal-binding globulin, TF, and is iron-binding blood plasma glycoproteins that control the level of free iron in biological fluids. Transferrins are iron binding transport proteins which bind Fe3+ ion in association with the binding of an anion, usually bicarbonate. Iron, insoluble as free Fe(3+) and toxic as free Fe(2+), is distributed through the body as Fe(3+) bound to transferrin (Tf) for delivery to cells by endocytosis of its complex with transferrin receptor (TfR).This transferrin binds only one Fe3+ ion per protein molecule.The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body.This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum.
生物活性
Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells.The EC50 for this effect is less than 5ng/ml.
电泳
- 1μg (R: reducing condition, N: non-reducing condition).
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