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ACE2 Fc Chimera Protein, Human

价格 ￥2,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA020026
规格
数量
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  • ACE2 Fc Chimera Protein, Human

    规格：25μg

    价格：￥2,000.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      Q9BYF1-1

    • 表达序列

      Gln18-Ser740, with C-terminal human IgG Fc

    • 表达宿主

      HEK293

    • 分子量

      110-140 kDa(Reducing)

    • 纯度

      ＞95% by SDS-PAGE

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • The angiotensin-converting enzyme 2 (ACE2) is the receptor for the three coronaviruses HCoV-NL63, SARS-CoV, and SARS-CoV-2. ACE2 is involved in the regulation of the renin-angiotensin system and blood pressure. ACE2 is also involved in the regulation of several signaling pathways, including integrin signaling. ACE2 expression is regulated transcriptionally and post-transcriptionally. The expression of the gene is regulated by two promoters, with usage varying among tissues. ACE2 expression is greatest in the small intestine, kidney, and heart and detectable in a variety of tissues and cell types. ACE2 receptors are ubiquitous and widely expressed in the heart, vessels, gut, lung (particularly in type 2 pneumocytes and macrophages), kidney, testis and brain. ACE2 is mostly bound to cell membranes and only scarcely present in the circulation in a soluble form. An important salutary function of membrane-bound and soluble ACE2 is the degradation of angiotensin II to angiotensi. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in SARS pathogenesis.

    • 生物活性

      • Anti-His antibody Immobilized on CM5 Chip captured Spike RBD His Tag, SARS-CoV-2 (BA.4/Omicron) (Cat. No. UA030024), can bind ACE2 Fc Chimera, Human (Cat. No. UA020026) with an affinity constant of 0.162 μM as determined in SPR assay (Biacore T200).

    • 电泳

      • 2μg (R: reducing conditions)

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