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产品中心 药物靶点和Fc受体 Fc受体类蛋白

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Fc γ RI/CD64 His Tag Protein, Mouse

CD64 antigen,CD64,CD64a,Fc fragment of IgG,high affinity Ia,receptor (CD64),Fc gamma RI,FCG1,Fc-gamma receptor I B2,Fc-gamma RI,Fc-gamma RIA,FcgammaRIa,FCGR1,FcgRI,FcgRIA,FCRI,FcRIA,FLJ18345,receptor for (CD64),high affinity immunoglobulin gamma Fc receptor I,IgG Fc receptor I

价格 ￥1,800.00 （ 1-2周）
货号 UA020020
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Mouse

  • 分子别名

    CD64 antigen, CD64, CD64a, Fc fragment of IgG, high affinity Ia, receptor (CD64), Fc gamma RI, FCG1, Fc-gamma receptor I B2, Fc-gamma RI, Fc-gamma RIA, FcgammaRIa, FCGR1, FcgRI, FcgRIA, FCRI, FcRIA, FLJ18345, high affinity Ia, receptor for (CD64), high affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I

  • Accession

    P26151-1

  • 表达序列

    Glu25-Pro297, with C-terminal His

  • 表达宿主

    HEK293

  • 分子量

    45-55kDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • Fc γ RI, also known as CD64, is a complete cell membrane glycoprotein, which transmits activation signals through the related Fc R γ chain, which is usually called Fc-γ RI 1 (Fc γ RI). The high affinity recognition of Fc γ RI to IgG allows it to trigger the effect response at low IgG concentration in the early immune response. After binding to IgG, CD64 interacts with an accessory chain called a common gamma chain, which has the ITAM motif necessary to trigger cells to activate. It is usually constitutively expressed on monocytes and macrophages and can be induced by neutrophils and eosinophils. Its expression is up-regulated in bacterial infections and sepsis. This product is produced by recombinant expression of mouse Fc γ RI from HEK293 cell line, which is purified, sterilized, filtered, packaged and freeze-dried.

  • 生物活性

    • Anti-His antibody Immobilized on CM5 Chip captured CD64 His Tag, Mouse (Cat. No. UA020020), can bind IgG1-Fc (UA050001) with an affinity constant of 0.109 μM as determined in SPR assay (Biacore T200).
    • Anti-His antibody Immobilized on CM5 Chip captured CD64 His Tag, Mouse (Cat. No. UA020020), can bind Pertuzumab with an affinity constant of 0.82 μM as determined in SPR assay (Biacore T200).

  • 电泳

    • Fc γ RI/CD64 His Tag, Mouse，2μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

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