Fc γ RIV/CD16-2 His Tag Protein, Mouse

Fc γ RIV/CD16-2,Low affinity immunoglobulin gamma Fc region receptor IV,CD16-2,Fc γ RIV

浏览次数：5

货号： UA020016

大包装询价

产品介绍评论(0)

产品规格

物种

Mouse
分子别名

Low affinity immunoglobulin gamma Fc region receptor IV；CD16-2；Fc γ RIV
Accession

A0A0B4J1G0-1
表达序列

Gly21-Gln203, with C-terminal His
表达宿主

HEK293
分子量

28-35kDa(Reducing)
纯度

＞95%, by SDS-PAGE under reducing conditions
内毒素含量

<0.1EU/μg
标记

Unconjugated
标签

His Tag
性状

Lyophilized powder
缓冲体系

PBS, pH7.4
溶解方法

Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
储存条件

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

背景介绍

Fc γ RIV (Low affinity immunoglobulin gamma Fc region receptor IV), also known as CD16-2 (Fc γ RIV), belongs to the Fc γ receptor family. Fc γ receptors can be divided into three types: Fc γ RI (CD64), Fc γ RII (CD32) and Fc γ RIII (CD16). Fc γ RI (CD64) has a high affinity for IgG monomers, while Fc γ RII (CD32) and Fc γ RIII (CD16) have relatively low affinity for IgG. Human CD16 is encoded by two genes, Fc γ RIIIA and Fc γ RIIIB. The gene sequence of CD16-2 is more similar to human Fc γ RIIIA protein. Fc γ RIV binding with IgG2a can promote osteocyte differentiation, while binding with IgE can promote macrophage-mediated phagocytosis, antigen presentation and pro-inflammatory cytokines production.

生物活性JSON
- Anti-His antibody Immobilized on CM5 Chip captured CD16-2 His Tag, Mouse (Cat. No. UA020016), can bind IgG1-Fc (UA050001) with an affinity constant of 0.177 μM as determined in SPR assay (Biacore T200).
- Anti-His antibody Immobilized on CM5 Chip captured CD16-2 His Tag, Mouse (Cat. No. UA020016), can bind Pertuzumab with an affinity constant of 0.211 μM as determined in SPR assay (Biacore T200).
电泳JSON
- Fc γ RIV/CD16-2 His Tag, Mouse，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.