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产品中心 药物靶点和Fc受体 Fc受体类蛋白

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Fc γ RIIB/CD32b His Tag Protein, Mouse

Fc gamma RIIB,CD32b,Fc gamma Receptor IIB/C,CD32,CDw32

价格 ￥1,800.00 （ 1-2周）
货号 UA020015
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Mouse

    • 分子别名

      Fc gamma RIIB , CD32b;;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32

    • Accession

      P08101-1

    • 表达序列

      Thr30-Arg208, with C-terminal His

    • 表达宿主

      HEK293

    • 分子量

      33-43kDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍

    • Fc γ RIIB, also known as CD32b, is a low affinity inhibitory receptor for the Fc part of the IgG molecule. It is a single-channel type I membrane protein with two IgG-like C2 (immunoglobulin-like) domains. Fc γ RIIB is expressed on B cells, macrophages, neutrophils, mast cells and bone marrow dendritic cells, and participates in B cell phagocytosis of immune complexes and regulation of antibody production. In some cases, it can promote cell apoptosis. CD32b may also be a target for monoclonal antibodies in the treatment of malignant tumors.

    • 电泳

      • Fc γ RIIB/CD32b His Tag, Mouse，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

    • SPR

      • NA/LE Mouse anti-human CD3 mAb (Cat. No. S0B0009) immobilized on CM5 Chip can bind Fc γ RIIB/CD32b His Tag Protein, Mouse (Cat. No. UA020015) with an affinity constant of 375 nM as determined in a SPR assay.

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