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物种
Cynomolgus分子别名
Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, FCG2, FCGR2A1, IGFR2Accession
Q8SPW4-1表达序列
Gln28-Pro208, with C-terminal His表达宿主
HEK293分子量
30-35kDa(Reducing)纯度
＞95%, by SDS-PAGE under reducing conditions内毒素含量
<0.1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
PBS, pH7.4溶解方法
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .储存条件
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three subtypes: RI (CD64), RII (CD32) and RIII (CD16). There are three human Fc γ RII / CD32 genes (A, B and C), two crab eating monkeys (An and B), and one Fc γ RII B in mice. Fc γ RIIA of cynomolgus monkey consists of extracellular domain, transmembrane domain and cytoplasmic domain. The extracellular domain includes two IgG domains. The Fc γ RIIA protein of crab-eating monkey has 89% homology with human Fc γ RIIA. CD32a is expressed in a variety of immune cells such as macrophages, neutrophils and platelets. When it binds to ligands, it initiates inflammatory responses, including cytolysis, phagocytosis, degranulation and production of cytokines. This response can be regulated by co-expression of inhibitory receptors such as CD32B.
生物活性
- Anti-His antibody Immobilized on CM5 Chip captured CD32a His Tag, Cynomolgus (Cat. No. UA020013), can bind IgG1-Fc (UA050001) with an affinity constant of 14.50 μM as determined in SPR assay (Biacore T200).
电泳
- Fc γ RIIA/CD32a His Tag, Cynomolgus，1μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.
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