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产品中心 药物靶点和Fc受体 Fc受体类蛋白

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Fc γ RIIB/CD32b His Tag Protein, Human

Fc γ RIIb,CD32b,Fc gamma Receptor IIB/C,CD32,CDw32

价格 ￥1,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA020003
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      Fc γ RIIb, CD32b;Fc gamma Receptor IIB/C, CD32, CD32b,CDw32

    • Accession

      P31994-1

    • 表达序列

      Ala46-Pro217, with C-terminal His

    • 表达宿主

      HEK293

    • 分子量

      27 -30 kDa(还原状态)

    • 纯度

      ＞98%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs is identified as three types: RI (CD64), RII (CD32) and RIII (CD16). Human Fc γ RII / CD32 has three genes, CD32A, B and C, respectively. CD32 is a low affinity Fc receptor. Low-affinity immunoglobulin Fc γ region receptor II-b, namely CD32b, also known as FCGR2B, FCG2, IGFR2. CD32b was expressed on B cells and myeloid dendritic cells. The co-junction of CD32b on dendritic cells inhibits maturation and prevents cell activation. CD32b may also be a target for monoclonal antibody therapy of malignant tumors.

    • 生物活性

      • Anti-His antibody Immobilized on CM5 Chip captured CD32b His Tag, Human (Cat. No. UA020003), can bind IgG1-Fc (UA050001) with an affinity constant of 14.9 μM as determined in SPR assay (Biacore T200).

    • 电泳

      • Fc γ RⅡb/CD32b His Tag, Human，1 μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 98%.

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