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产品中心 药物靶点和Fc受体 药物靶点

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MUC17 His Tag Protein, Human

Mucin-17,MUC-17,Small intestinal mucin-3 (MUC-3),MUC3

价格 ￥1,100.00 （ 1-2周）
货号 UA019065
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Mucin-17, MUC-17, Small intestinal mucin-3 (MUC-3), MUC3

  • Accession

    Q685J3

  • 表达序列

    Protein sequence (Q685J3, Lys4120-Try4338, with C-His Tag) KSNPTSTPTVPRTTTCFGDGCQNTASRCKNGGTWDGLKCQCPNLYYGELCEEVVSSIDIGPPETISAQMELTVTVTSVKFTEELKNHSSQEFQEFKQTFTEQMNIVYSGIPEYVGVNITKLRLGSVVVEHDVLLRTKYTPEYKTVLDNATEVVKEKITKVTTQQIMINDICSDMMCFNTTGTQVQNITVTQYDPEEDCRKMAKEYGDYFVVEYRDQKPY

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 26.5 kDa Observed MW: 19-30 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Mucin-17 is a protein that in humans is encoded by the MUC17 gene. Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.

  • 生物活性

    • Immobilized Human MUC17 Protein, His Tag at 2 μg/mL (100 μL/well) can bind MUC17 Recombinant Rabbit mAb (SDT-1415-49) (Cat. No. S0B2344) with EC50 of 1.8-2.2 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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