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物种
Mouse分子别名
T-cell surface protein tactile, Cell surface antigen CD96, T cell-activated increased late expression proteinAccession
Q3U0X8表达序列
Protein sequence (Q3U0X8, Val22-Met536, with C-His tag) VWEELFNVGDDVYALPGSDINLTCQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWTLYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPYTQDEHNYTIEIETNRTLEIPCFQNTSSEIPPRFTFSWLVEKDGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQIQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNVFPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHSGPSQSNNMTAWCMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYLATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWPFPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHDTIISTTTEFPNVLTTANGTTKIDHGPITSIIVNQPSDGM
表达宿主
HEK293分子量
Predicted MW: 58.5 kDa Observed MW: 100-130 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
CD96 (also known as TACTILE) is an immune checkpoint protein belonging to the immunoglobulin superfamily, closely related to TIGIT and CD226 (DNAM-1). It is primarily expressed on natural killer (NK) cells and T cells, where it interacts with its ligand, CD155 (PVR), and to a lesser extent, CD112 (PVRL2). CD96 functions as a co-inhibitory receptor, dampening immune responses by competing with the activating receptor CD226 for the same ligands.
生物活性
Immobilized Mouse CD96 Protein, His Tag at 2 μg/mL (100 μL/well) can bind Recombinant Mouse PVR/CD155 Protein, C-hFc&Avi with EC50 of 99-126 ng/ml.
电泳
2μg（R: reducing conditions）
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