热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/2）

FcGRT&B2M Heterodimer His Tag Protein, Human

FcRn,FCGRT & B2M

价格 ￥1,000.00 （ 1-2周）
货号 UA019062
规格
数量
收藏 分享
产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    FcRn, FCGRT & B2M

  • Accession

    P55899, P61769

  • 表达序列

    Protein sequence (P55899, Ala24-Ser297, with C-His Tag) AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSS Protein sequence (P61769, Ile21-Met119) IQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 32.1 kDa(FcGRT)&11.7 kDa(B2M) Observed MW: 11, 33 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签蛋白&酶切位点

    with C-His Tag (FcGRT)&No tag (B2M)

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • FcRn is a critical protein responsible for regulating the lifespan and transport of immunoglobulin G (IgG) antibodies. Primarily located in endothelial and phagocytic cells, FcRn binds to IgG in acidic endosomes, recycling them back to the cell surface and releasing them into circulation at a neutral pH. This unique pH-dependent binding mechanism protects IgG from lysosomal degradation, significantly extending its serum half-life. Additionally, FcRn mediates the transcytosis of IgG across placental and epithelial barriers, facilitating passive immunity from mother to offspring and mucosal immune defense. Its role makes it a major therapeutic target for modulating antibody-based therapies.

  • 生物活性

    • Anti-His antibody Immobilized on CM5 Chip captured Human FcGRT&B2M Heterodimer Protein, His Tag, can bind Anti-human Claudin 18.2 Monoclonal Antibody (zolbetuximab) (Cat. No. S0B1436) with an affinity constant of 0.41μM as determined in SPR assay.

  • 电泳

    • 2 μg（R: reducing conditions）

评论(0)