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产品中心 药物靶点和Fc受体 药物靶点

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IGFBP5 hFC Tag Protein, Human

Insulin-like growth factor-binding protein 5,IBP-5,IGF-binding protein 5,IGFBP-5,IBP5

价格 ￥500.00 （ 1-2周）
货号 UA019052
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    Insulin-like growth factor-binding protein 5, IBP-5, IGF-binding protein 5, IGFBP-5, IBP5

  • Accession

    P24593

  • 表达序列

    Protein sequence (P24593, Leu21-Glu272, with C-hFC tag) LGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 54.6 kDa Observed MW: 30, 31, 33, 40, 70 kDa

  • 纯度

    ＞90% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied.
    6 months, -20 to -70 °C under sterile conditions after reconstitution.
    1 week, 2 to 8 °C under sterile conditions after reconstitution.
    Please avoid repeated freeze-thaw cycles.

背景介绍

  • Insulin-like growth factor-binding protein 5 (IGFBP5) is a key member of the IGFBP family, which regulates the bioavailability and activity of insulin-like growth factors (IGFs). Expressed in various tissues, IGFBP5 modulates cell proliferation, differentiation, and apoptosis through IGF-dependent and IGF-independent mechanisms. It interacts with extracellular matrix components and influences signaling pathways like MAPK and PI3K. IGFBP5 is implicated in physiological processes (e.g., bone development, wound healing) and pathologies, including cancer and fibrosis.

  • 生物活性

    • Immobilized Human IGFBP5 Protein, hFc Tag at 4 μg/mL (100 μL/well) can bind Recombinant Human IGF-I Protein, C-hFc&His with EC50 of 79.6-89.4 ng/ml.

  • 电泳

    • 2μg（R: reducing conditions）

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