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产品中心 药物靶点和Fc受体 药物靶点

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Fc γ RIa/CD64 His Tag Protein, Human

IgG Fc receptor I,Fc-gamma RI (FcRI),Fc-gamma RIA (FcgammaRIa),FCG1,FCGR1,IGFR1

价格 ￥500.00 （ 1-2周）
货号 UA019044
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    IgG Fc receptor I, Fc-gamma RI (FcRI), Fc-gamma RIA (FcgammaRIa), FCG1, FCGR1, IGFR1

  • Accession

    P12314

  • 表达序列

    Protein sequence (P12314, Gln16-His292, with C-10*His) QVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHGGGGSHHHHHHHHHH

  • 表达宿主

    HEK293

  • 分子量

    Predicted MW: 32.9 kDa Observed MW: 45-55 kDa

  • 纯度

    ＞95% by SDS-PAGE

  • 内毒素含量

    <1EU/μg

  • 标签

    His Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

  • 溶解方法

    Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.

  • 储存条件

    12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

背景介绍

  • CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity. It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation. Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail. CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.

  • 生物活性

    • Immobilized Human IgG1 Fc (S0A0052) at 4 μg/mL (50 μL/well) can bind Human Fc γ RIa/CD64, His tag with EC50 of 7.520-9.702 ng/ml.

    • Immobilized Pembrolizumab (S0B0233) at 2 μg/mL (50 μL/well) can bind Human Fc γ RIa/CD64, His tag with EC50 of 2.854-3.591 ng/ml.

  • 电泳

    • 2 μg（R: reducing conditions）

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