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物种
Human分子别名
Transforming growth factor beta-1 proprotein, TGFB1, TGFBAccession
P01137表达序列
Protein sequence (P01137, Met1-Ser390, with C-His Tag) MPPSGLRLLPLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
表达宿主
HEK293分子量
Predicted MW: 46.5 kDa Observed MW: 15, 40, 55 kDa纯度
＞95% by SDS-PAGE内毒素含量
<1EU/μg标记
Unconjugated标签
His Tag性状
Lyophilized Powder缓冲体系
Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4 with 3% trehalose.
溶解方法
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.储存条件
12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.
TGFB1 (Transforming Growth Factor Beta 1) is a multifunctional cytokine belonging to the TGF-β superfamily, playing crucial roles in cell proliferation, differentiation, apoptosis, and immune regulation. It is secreted by various cell types, including immune cells, and functions in both autocrine and paracrine signaling. TGFB1 is pivotal in wound healing, fibrosis, and maintaining tissue homeostasis, but its dysregulation is linked to cancer, autoimmune diseases, and fibrotic disorders. It signals through SMAD-dependent and non-SMAD pathways, modulating gene expression.
生物活性
Immobilized Human TGF-β1 Protein, His Tag at 2 μg/mL (100 μL/well) can bind Recombinant Human TGFBR2 (C-Fc) with EC50 of 16-19 ng/ml.
电泳
2μg（R: reducing conditions）
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